Detalhe da pesquisa
1.
Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors.
J Org Chem
; 88(19): 13727-13740, 2023 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751412
2.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591316
3.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33509903
4.
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J Biol Chem
; 291(30): 15778-87, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226591
5.
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nat Chem Biol
; 10(8): 629-31, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997604
6.
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems.
J Org Chem
; 81(9): 3509-19, 2016 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056793
7.
Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium.
J Mol Cell Cardiol
; 89(Pt B): 365-75, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26432951
8.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
9.
Improving on nature: making a cyclic heptapeptide orally bioavailable.
Angew Chem Int Ed Engl
; 53(45): 12059-63, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25219505
10.
Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Drug Metab Dispos
; 41(8): 1470-9, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23653442
11.
Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(3): 1497-506, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22239115
12.
Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.
J Org Chem
; 77(22): 10050-7, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23127254
13.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23153798
14.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
J Med Chem
; 65(12): 8208-8226, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647711
15.
Excretion, metabolism, and pharmacokinetics of CP-945,598, a selective cannabinoid receptor antagonist, in rats, mice, and dogs.
Drug Metab Dispos
; 39(12): 2191-208, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21875952
16.
Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Bioorg Med Chem Lett
; 21(9): 2641-5, 2011 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21295475
17.
Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial.
Nat Med
; 27(6): 1079-1087, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34127852
18.
In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity.
Biochem Biophys Res Commun
; 394(2): 366-71, 2010 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20211605
19.
Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Chem Res Toxicol
; 23(6): 1115-26, 2010 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20507089
20.
Quantitative in vitro and in vivo pharmacological profile of CE-178253, a potent and selective cannabinoid type 1 (CB1) receptor antagonist.
BMC Pharmacol
; 10: 9, 2010 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20712891